Factors Affecting Dissolution Rate
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چکیده
Solubility of drug plays a prime role in controlling its dissolution from dosage form. Aqueous solubility of drug is a major factor that determines its dissolution rate. Minimum aqueous solubility of 1% is required to avoid potential solubility limited absorption problems. Studies of 45 compound of different chemical classes and a wide range of solubilities revealed that initial dissolution rate of these substances is directly proportional to their respective solubilities. Fig shows a log-log plot of solubilities of several drug Vs their corresponding intrinsic rates of dissolution at infinite rotation speed. Evident from graph that compounds with high solubilities exhibit significantly higher dissolution rates.
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